In the supplementation maelstrom, we had the pleasure of talks with Konrad PalkaCEO of Endotheliumthe range of supplements , based on the compound 1-MNAa metabolite of niacin (vitamin B3) that contributes to the natural increase in NAD⁺, a coenzyme essential for cellular energy production, DNA repair and metabolic function. Recent studies show that NAD⁺ levels can decrease by up to 50 % between the ages of 40 and 60.This has a negative impact on vitality, cell regeneration and general health.
Endotelio products are developed on a sound scientific basis, with clinical backing and approval as a "new food" by the European Food Safety Authority (EFSA).). The multifactorial action of 1-MNA is linked to key benefits in vascular function, reduction of inflammation, physical performance, neurocellular protection, and neuroprotection.activation of sirtuin-related longevity pathways SIRT1.
The range includes different formulas for specific needs. Endothelium in its base version provides only 1-MNA, ideal for those seeking an overall improvement in cellular metabolism and energy performance. The line Cellular Energy It also incorporates CoQ10, B vitamins and magnesium to combat physical fatigue. Brain combines 1-MNA with ginkgo biloba, zinc and vitamin C. to support cognitive function and concentration. Immune boosts the immune system with vitamin D, C, selenium and other essential micronutrients.. And the most powerful version, Endothelium PROoffers twice the daily dose of 1-MNA, designed for those seeking intensive intervention in cellular regeneration processes.
Konrad Palka, CEO of the company, explains how to choose the right supplement: "The best is Endothelium PRO, which contains a double dose of 1-MNA. The rest are combinations with other ingredients, so it depends on the customer's needs. It also clarifies that no prescription is needed to purchase them.The fact that these are freely available food supplements does not mean, however, that a prescription for consumption and dosage is not useful. But the fact that you do not need to buy them does not mean that a prescription for consumption and dosage is not useful, as it is quite logical that a normal user does not know his real nutritional needs, and even less so with regard to a "new" food of which he only knows the name.
Regarding the duration of treatment, Palk recommends "a minimum of 2 to 3 months, although for prolonged cellular support and best results, it is best to maintain use over time.". The supplements are suitable for all adults, except pregnant and breastfeeding women. On possible side effects, he says: "No adverse effects with prolonged use".
The added value of this range lies in its precise, accessible and clinically supported approach, offering real solutions for those seeking to maintain their energy, mental clarity, immunity and vascular health. in optimal conditions. In a context where cellular ageing is a growing concern, Endotelio proposes an effective and safe tool to accompany a healthy diet and a conscious lifestyle, which seems to be a concept that can be interpreted differently and is certainly the most difficult to achieve.
Although they are designed to be safe and effective in a large adult population, widespread use without medical advice raises questions about their personalisation and individual effectiveness.
From a scientific and regulatory point of view, food supplements are not intended to treat diseases, but rather to maintain or support normal physiological functions. As such, they can be marketed without a prescription. In the case of 1-MNA, its safety has been assessed and approved by health authorities such as EFSA, which supports its general use in healthy adults.
However, the effectiveness and relevance of the supplement will depend on health status, lifestyle, metabolism and personal goals. of each user. This is where the "personalisation without prescription" approach comes into play: instead of tailoring the formula to each individual (as a doctor would do), the brand provides different combinations according to common needsenergy, brain, immune system, etc.
In addition, Endothelium's CEO suggests a responsible self-management oriented model, where the user chooses the supplement based on their mild symptoms or optimisation desires (fatigue, stress, ageing, etc.). This is complemented by general recommendations for use, but does not replace a medical evaluation if there are specific conditions.
