{"id":5329,"date":"2025-09-26T19:07:46","date_gmt":"2025-09-26T17:07:46","guid":{"rendered":"https:\/\/wellnessforum.pro\/?p=5329"},"modified":"2025-09-26T19:13:29","modified_gmt":"2025-09-26T17:13:29","slug":"vitamin-b3-supplement-opens-door-to-anti-ageing-therapies-chiba-university-findings","status":"publish","type":"post","link":"https:\/\/wellnessforum.pro\/en\/un-suplemento-de-vitamina-b3-abre-la-puerta-a-terapias-contra-el-envejecimiento-hallazgos-de-la-universidad-de-chiba\/","title":{"rendered":"Vitamin B3\" supplement opens the door to anti-ageing therapies: Chiba University findings"},"content":{"rendered":"<p><em>The latest clinical trial in patients with Werner's syndrome, a rare accelerated ageing disease, shows that raising NAD\u207a levels with nicotinamide riboside improves vascular, skin and kidney health. The news reinforces the credibility of those in their 50s and older who seek to prevent cellular decline through NAD\u207a supplementation.<\/em><\/p>\n\n\n\n<p>In April 2025, a team from the <strong>Chiba University Graduate School of Medicine<\/strong> (Japan), led by <strong>Masaya Koshizaka<\/strong> y <strong>Koutaro Yokote<\/strong>he published in <em>Aging Cell<\/em> the results of a double-blind, randomised, crossover clinical trial involving 26 patients with <strong>Werner's syndrome<\/strong> (WS), a genetic disease characterised by premature ageing.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/progeria-wide-1024x576.jpg\" alt=\"\" class=\"wp-image-5331\" srcset=\"https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/progeria-wide-1024x576.jpg 1024w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/progeria-wide-300x169.jpg 300w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/progeria-wide-768x432.jpg 768w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/progeria-wide-18x10.jpg 18w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/progeria-wide.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>For 26 weeks, participants took <strong>1,000 mg daily of <a href=\"https:\/\/naddirect.com\/products\/nrx-optima-max?sca_ref=9474126.9sJBAqmGJE\">nicotinamide riboside (NR)<\/a><\/strong>a precursor of NAD\u207a, and then crossed to placebo (and vice versa). The results were clear:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Significantly improved the <strong>arterial stiffness<\/strong> (CAVI index).<\/li>\n\n\n\n<li>The <strong>total area of skin ulcers<\/strong>a common complication in WS.<\/li>\n\n\n\n<li>The <strong>blood creatinine<\/strong>a sign of renal protection.<\/li>\n\n\n\n<li>And the most relevant: <strong>no serious adverse effects were recorded<\/strong>although some subjects showed slight alterations in liver enzymes.<\/li>\n<\/ul>\n\n\n\n<p>\"These findings suggest that restoring NAD\u207a may help not only patients with accelerated ageing, but also older adults with physiological ageing,\" the authors conclude.<\/p>\n\n\n\n<p><strong>NAD\u207a: the cellular fuel that declines with age<\/strong><\/p>\n\n\n\n<p>The <strong>NAD\u207a (nicotinamide adenine dinucleotide)<\/strong> is a vital coenzyme in all our cells: it is involved in mitochondrial energy production, DNA repair and regulation of metabolism. From <strong>40-50 years<\/strong>levels naturally fall, contributing to fatigue, poorer muscle function and increased vulnerability to oxidative damage.<\/p>\n\n\n\n<p>Hence, many international teams - such as the one from <strong>Vilhelm A. Bohr<\/strong> (NIH, Baltimore; University of Copenhagen) - investigate the impact of supplementing NAD\u207a precursors (NR or NMN) in the over 50s.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/antiaging-con-nad-1024x576.jpg\" alt=\"\" class=\"wp-image-5332\" srcset=\"https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/antiaging-con-nad-1024x576.jpg 1024w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/antiaging-con-nad-300x169.jpg 300w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/antiaging-con-nad-768x432.jpg 768w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/antiaging-con-nad-18x10.jpg 18w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/antiaging-con-nad.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><strong>What does the science say about the over 50s?<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Martens et al., 2018 (University of Colorado):<\/strong> NR improved arterial stiffness in adults aged 55-79 years with mild hypertension.<\/li>\n\n\n\n<li><strong>Dollerup et al., 2019 (University of Copenhagen):<\/strong> in patients with obesity and insulin resistance, NR raised plasma NAD\u207a but did not improve insulin sensitivity.<\/li>\n\n\n\n<li><strong>Yoshino et al., 2021 (Washington University):<\/strong> NMN increased aerobic capacity and insulin sensitivity in pre-diabetic postmenopausal women.<\/li>\n\n\n\n<li><strong>Reviews 2024-2025<\/strong> conclude that supplementation reliably raises blood NAD\u207a and is safe in the short term, although clinical benefits vary according to age, sex and pathology.<\/li>\n<\/ul>\n\n\n\n<p>In sum, the evidence is still emerging, but it lends increasing credence to those who seek to <strong>supporting cellular and mitochondrial health<\/strong> with NAD\u207a supplementation from the age of 50.<\/p>\n\n\n\n<p><strong>How to tell if you have low NAD\u207a levels<\/strong><\/p>\n\n\n\n<p>Laboratory tests are now available to estimate the availability of NAD\u207a in the body:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>LC-MS\/MS (liquid chromatography + mass spectrometry):<\/strong> the most accurate method, used in clinical research.<\/li>\n\n\n\n<li><strong>Enzyme cycling assays:<\/strong> more affordable and useful for group monitoring.<\/li>\n\n\n\n<li><strong>Rapid capillary puncture tests:<\/strong> still under validation, but they promise to measure the \"NADome\" in an accessible way.<\/li>\n<\/ul>\n\n\n\n<p>However, <strong>there are no universal clinical reference values<\/strong>interpretation depends on age, sample and clinical context.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"700\" height=\"700\" src=\"https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/2_95203ba3-7aa4-4ef3-bb69-63a076e357fa.webp\" alt=\"\" class=\"wp-image-5333\" srcset=\"https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/2_95203ba3-7aa4-4ef3-bb69-63a076e357fa.webp 700w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/2_95203ba3-7aa4-4ef3-bb69-63a076e357fa-300x300.webp 300w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/2_95203ba3-7aa4-4ef3-bb69-63a076e357fa-150x150.webp 150w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/2_95203ba3-7aa4-4ef3-bb69-63a076e357fa-12x12.webp 12w, https:\/\/wellnessforum.pro\/wp-content\/uploads\/2025\/09\/2_95203ba3-7aa4-4ef3-bb69-63a076e357fa-650x650.webp 650w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/figure>\n\n\n\n<p><strong>Tips before supplementing<\/strong><\/p>\n\n\n\n<p>Experts agree: if you are considering starting NAD\u207a supplementation, it is essential:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Consult a doctor<\/strong>especially in case of chronic diseases, medication use or a history of cancer.<\/li>\n\n\n\n<li><strong>Choosing brands with the highest quality and evidence of purity<\/strong>avoiding products without clinical support or of dubious origin. Specialised clinics such as <a href=\"https:\/\/naddirect.com?sca_ref=9474126.9sJBAqmGJE\"><strong>NAD Clinic<\/strong> <\/a>offer reference products in Europe and the USA.<\/li>\n\n\n\n<li>For readers interested in improving their <strong>energy, cell function and longevity<\/strong>there is the option of <a href=\"https:\/\/naddirect.com?sca_ref=9474126.9sJBAqmGJE\">to purchase products with a <strong>10% discount<\/strong><\/a> by entering the code <strong>WF10<\/strong>.<\/li>\n<\/ol>\n\n\n\n<p><br>The Chiba trial is not yet definitive proof, but it is a firm step: restoring NAD\u207a can improve central aspects of ageing. Science will continue to answer the remaining questions, but the idea of supporting cellular longevity is no longer science fiction.<\/p>\n\n\n\n<p>Scientific references<\/p>\n\n\n\n<p>Shoji M. et al. <em>Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.<\/em> Aging Cell. 2025.<\/p>\n\n\n\n<p>Martens CR. et al. <em>Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD\u207a in healthy middle-aged and older adults.<\/em> Nat Commun. 2018.<\/p>\n\n\n\n<p>Dollerup OL. et al. <em>Nicotinamide riboside does not improve insulin sensitivity in obese men with prediabetes.<\/em> J Clin Endocrinol Metab. 2019.<\/p>\n\n\n\n<p>Yoshino J. et al. <em>Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.<\/em> Science. 2021.<\/p>\n\n\n\n<p>Elhassan YS. et al. <em>Nicotinamide riboside augments human skeletal muscle NAD\u207a metabolism and alters mitochondrial function.<\/em> Cell Metab. 2019.<\/p>\n\n\n\n<p>Airhart SE. et al. <em>An open-label, non-randomized study of NR supplementation in healthy volunteers.<\/em> PLoS One. 2017.<\/p>\n\n\n\n<p>Liu L. et al. <em>Decline of NAD\u207a with age and therapeutic potential of NAD\u207a restoration.<\/em> Nat Rev Drug Discov. 2018.<\/p>\n\n\n\n<p>Katsyuba E., Auwerx J. <em>Modulating NAD\u207a metabolism, from bench to bedside.<\/em> EMBO J. 2017.<\/p>\n\n\n\n<p>Rajman L, Chwalek K, Sinclair DA. <em>Therapeutic potential of NAD\u207a precursors in aging and disease.<\/em> Nat Rev Drug Discov. 2018. <\/p>\n\n\n\n<p>De Picciotto NE. et al. <em>NAD\u207a precursor supplementation and vascular function in aging.<\/em> Circ Res. 2020.<\/p>","protected":false},"excerpt":{"rendered":"<p>El ensayo cl\u00ednico m\u00e1s reciente en pacientes con s\u00edndrome de Werner, una rara enfermedad de envejecimiento acelerado, muestra que elevar los niveles de NAD\u207a con nicotinamida rib\u00f3sido mejora la salud vascular, cut\u00e1nea y renal. La noticia refuerza la credibilidad de quienes a partir de los 50 a\u00f1os buscan prevenir el declive celular mediante suplementos de [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5330,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162],"tags":[],"class_list":["post-5329","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Un suplemento de \u201cvitamina B3\u201d abre la puerta a terapias contra el envejecimiento: hallazgos de la Universidad de Chiba<\/title>\n<meta name=\"description\" content=\"elevar los niveles de NAD\u207a con nicotinamida rib\u00f3sido mejora la salud vascular, cut\u00e1nea y renal. 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